![]() ![]() What is the neuronal basis of the brain circadian clock: we study the behavioral contribution of the different neuronal oscillators and their communication through neuropeptides (PDF and ITP) or other neurotransmitters to understand the rules operating in the clock neuronal network.How natural genetic variation shapes individual sleep-wake rhythm phenotypes in various environmental conditions: we analyze the behavior of fully sequenced isogenic lines derived from individuals caught in the wild to identify new variants of clock and light-input components.How does the molecular machinery that is running in the clock cells generate a 24h (circadian) oscillation: we analyze the function and regulation (transcriptional, post-transcriptional and post-translational controls) of key clock genes (Clock, period, timeless) and search for new clock components.Our projects address the following questions. ![]()
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